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It has been established that gliomas are the most common primary central nervous system neoplasms, while Lung cancer is the leading category of cancer death in men, and—since the late 1980s—it has surpassed breast cancer as the leading category of cancer death in women. ContraCancrum will integrate and optimise the simulator for implementing two clinical studies-scenarios corresponding to the two tumour types to be considered. Six University Hospital Departments possessing world acclaimed expertise in running clinical trials will provide multilevel and multimodality sets of data for about 200 patients per year (including both glioma and lung cancer cases).